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Levering af eksogen kunstigt syntetiseret miRNA-efterligning til nyrerne ved hjælp af polyethylenaminnanopartikler i flere nyresygdomsmusemodeller
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Levering af eksogen kunstigt syntetiseret miRNA-efterligning til nyrerne ved hjælp af polyethylenaminnanopartikler i flere nyresygdomsmusemodeller

Article DOI: 10.3791/63302-v • 07:01 min • May 10th, 2022
May 10th, 2022 •
*1, 1, 1, 1, *1
1Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University
* These authors contributed equally

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Her leverer vi eksogene kunstigt syntetiserede miRNA-efterligninger til nyrerne via haleveneinjektion af en ikke-viral vektor og polyethylenaminnanopartikler i flere nyresygdomsmusemodeller. Dette førte til signifikant overekspression af mål-miRNA i nyrerne, hvilket resulterede i hæmmet progression af nyresygdom i flere musemodeller.

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Medicin udgave 183 genterapi levere nyresygdomme microRNA ikke-viral vektor polyethylenimin nanopartikel
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