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JoVE Journal Bioengineering
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Un sistema microfisiológico para estudiar la interacción leucocitario-endotelial durante la inflamación

Article DOI: 10.3791/63312-v • 12:55 min • December 9th, 2021
December 9th, 2021 •
1, 2, 3, 4, 5, 1,2,6
1Department of Mechanical Engineering, Temple University, 2Department of Bioengineering, Temple University, 3Department of Bioengineering, University of Toledo, 4Biomedical Technology, CFD Research Corporation, 5Center for Inflammation and Lung Research, Department of Microbiology, Immunology and Inflammation, Lewis Katz School of Medicine, Temple University, 6Department of Radiation Oncology, Lewis Katz School of Medicine, Temple University

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En este protocolo, se emplea un ensayo biomimético de microfluidos, que puede reproducir un entorno microvascular fisiológicamente relevante y reproducir toda la cascada de adhesión/migración de leucocitos, para estudiar las interacciones leucocitarios-células endoteliales en la enfermedad inflamatoria.

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Bioingeniería Número 178 sistema microfisiológico interacción leucocito-célula endotelial inflamación adhesión migración ensayo biomimético de microfluidos
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