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JoVE Journal Neuroscience
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Analysere Parkinsons sykdom Musemodell indusert av Adeno-assosierte Viral Vectors Koding Human α-Synuclein

Article DOI: 10.3791/63313-v • 14:45 min • July 29th, 2022
July 29th, 2022 •
1, 1, 1, 1, 2, 2,3,4, 1,5
1Laboratorio de Neuroinmunología, Fundación Ciencia & Vida, 2Center for Integrative Biology, Universidad Mayor, 3FONDAP Geroscience Center for Brain Health and Metabolism, 4Buck Institute for Research on Ageing, 5Facultad de Medicina y Ciencia, Universidad San Sebastián

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Dette arbeidet analyserer vektordosen og eksponeringstiden som kreves for å indusere nevroinflammasjon, nevrodegenerasjon og motorisk svekkelse i denne prekliniske modellen av Parkinsons sykdom. Disse vektorene som koder den menneskelige α-synuclein leveres inn i substantia nigra for å rekapitulere synukleinpatologien forbundet med Parkinsons sykdom.

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Nevrovitenskap utgave 185 Parkinsons sykdom adeno-assosierte virusvektorer α-synuklein nevroinflammasjon nevrodegenerasjon musemodell
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