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JoVE Journal Neuroscience
Osmotisk pumpebasert legemiddellevering for In Vivo Remyelination Research on the Central Nervous System
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Osmotisk pumpebasert legemiddellevering for In Vivo Remyelination Research on the Central Nervous System

Article DOI: 10.3791/63343-v • 06:07 min • December 17th, 2021
December 17th, 2021 •
1, 1,2, 1,3, 1
1Department of Histology and Embryology, Chongqing Key Laboratory of Neurobiology, Brain, and Intelligence Research Key Laboratory of Chongqing Education Commission, Third Military Medical University, 2Research Centre, The Seventh Affiliated Hospital of Sun Yat-sen University, 3School of Medicine, Chongqing University

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Demyelinering foregår i flere sykdommer i sentralnervesystemet. En pålitelig in vivo-medikamentleveringsteknikk er nødvendig for å remyelinisere legemiddeltesting. Denne protokollen beskriver en osmotisk pumpebasert metode som tillater langsiktig legemiddellevering direkte inn i hjernen parenchyma og forbedrer stoffet biotilgjengelighet, med bred anvendelse i remyelination forskning.

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