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JoVE Journal Neuroscience
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In vivo Positron Emission Tomography to Reveal Activity Patterns Induced by Deep Brain Stimulation in Rats

Article DOI: 10.3791/63478-v • 09:36 min • March 23rd, 2022
March 23rd, 2022 •
1, 2,3, 2,3, 1,2,3,4, 2,4,5
1Centro Nacional de Investigaciones Cardiovasculares (CNIC), 2Laboratorio de Imagen Médica, Instituto de Investigación Sanitaria Gregorio Marañón, 3Departamento de Bioingeniería e Ingeniería Aeroespacial, Universidad Carlos III de Madrid, 4CIBER de Salud Mental (CIBERSAM), 5High Performance Research Group in Physiopathology and Pharmacology of the Digestive System (NeuGut), Universidad Rey Juan Carlos

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Summary
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We describe a preclinical experimental method to evaluate metabolic neuromodulation induced by acute deep brain stimulation with in vivo FDG-PET. This manuscript includes all experimental steps, from stereotaxic surgery to the application of the stimulation treatment and the acquisition, processing, and analysis of PET images.

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In Vivo Positron Emission Tomography Deep Brain Stimulation Rats Stimulation Consequences Neural Networks DBS Impact On Brain Dynamics FD Repair Stimulation Protocols Neurology Psychiatry CT Imaging MRI Imaging Stereotactic Frame Image Processing Software Spatial Normalization Bregma Line AP Access ML Access DV Access
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