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Performing In Vivo and Ex Vivo Electrical Impedance Myography in Rodents

Article DOI: 10.3791/63513-v • 05:44 min • June 8th, 2022
June 8th, 2022 •
1, 1, 1, 1, 1, 2, 3, 1
1Department of Neurology, Harvard Medical School - Beth Israel Deaconess Medical Center, 2Accelerating NeuroVentures, 3Charley's Fund

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This article details how to perform in vivo (using surface and needle electrode arrays) and ex vivo (using a dielectric cell) electrical impedance myography on the rodent gastrocnemius muscle. It will demonstrate the technique in both mice and rats and detail the modifications available, (i.e., obese animals, pups).

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Performing In Vivo Ex Vivo Electrical Impedance Myography Rodents Muscle Condition Diagnostic Tool Biomarker Quantitative Index Disease Status Therapeutic Study Skeletal Muscle Pathology Histological Alterations Surface Measurements Contact Impedance Artifacts Mouse Prone Position Toe Pinching Test Leg Analysis 45 Degree Angle Knee Extended Medical Tape Fur Trimming Depilatory Cream Saline Saturated Gauze Surface Array Electrodes
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