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A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
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A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

Article DOI: 10.3791/63526-v • 07:09 min • February 18th, 2022
February 18th, 2022 •
*1,2, *1,3, *1, *1, 2, 1, 1, 1, 1
1Guangdong Laboratory Animals Monitoring Institute, 2Department of Cardiovascular Surgery, the First Affiliated Hospital, Jinan University, 3College of Veterinary Medicine, South China Agricultural University
* These authors contributed equally

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Summary
Automatic Translation

The present protocol describes a step-by-step procedure to establish a minipig model of heart failure with preserved ejection fraction using descending aortic constriction. The methods for evaluating cardiac morphology, histology, and function of this disease model are also presented.

Tags

Surgical Model Heart Failure Preserved Ejection Fraction Tibetan Minipigs Large Animal Model Descending Aortic Constriction Chronic Pressure Overload Left Ventricle Echocardiography Morphological Changes Functional Changes Ventricular Septum Hypertrophy Posterior Wall Thickness Reduction Left Ventricle Dilation LV Ejection Fraction Cardiac Damage Fibrosis Inflammation Cardiomyocyte Hypertrophy Heart Failure Markers Molecular Mechanisms
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