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Journal / Biochemistry / Fingerprinting Cardiolipin nei leucociti mediante …
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Biochemistry

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JoVE Journal Biochemistry
Fingerprinting Cardiolipin nei leucociti mediante spettrometria di massa per una diagnosi rapida della sindrome di Barth
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Fingerprinting Cardiolipin nei leucociti mediante spettrometria di massa per una diagnosi rapida della sindrome di Barth

Article DOI: 10.3791/63552-v • 06:48 min • March 23rd, 2022
March 23rd, 2022 •
*1, *2, 2, 2
1Medical School, Swansea University, 2Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro
* These authors contributed equally

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Questo protocollo mostra come ottenere una "impronta digitale" spettrometrica di massa della cardiolipina leucocitaria per la diagnosi della sindrome di Barth. La valutazione dell'elevato rapporto tra monolisocardiolipina e cardiolipina discrimina i pazienti con sindrome di Barth dai pazienti con insufficienza cardiaca di controllo con sensibilità e specificità al 100%.

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Biochimica Numero 181
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