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Neuroscience

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JoVE Journal Neuroscience
Brug af en cellesporingsinjektion til at undersøge oprindelsen af neointima-dannende celler i en rottesakkulære sidevægsmodel
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Brug af en cellesporingsinjektion til at undersøge oprindelsen af neointima-dannende celler i en rottesakkulære sidevægsmodel

Article DOI: 10.3791/63580-v • 05:41 min • March 16th, 2022
March 16th, 2022 •
*1,2, *1,2, 1,2, 1,2, 2, 1,2, 3, 4, 1,2,5, 1,2,5
1Department of Neurosurgery, Kantonsspital Aarau, 2Cerebrovascular Research Group, Department for BioMedical Research, University of Bern, 3Institute of Pathology Laenggasse, 4Department of Neurosurgery, Neurocenter and Regenerative Neuroscience Cluster, Inselspital, Bern University Hospital, University of Bern, 5Faculty of Medicine, University of Bern
* These authors contributed equally

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Vi udførte en en-punkts, lipofil celle-sporstofinjektion for at spore endotelceller, efterfulgt af en arteriotomi og suturering af sidevægsaneurismer på abdominal rotte aorta. Neointima dannelse syntes afhængig af moderarterien i decellulariserede aneurismer og blev fremmet ved rekruttering fra aneurismevægceller i vitale cellerrige vægge.

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Neurovidenskab udgave 181 Helsinki rotte mikrokirurgisk sidevæg aneurisme model endovaskulær terapi celle-sporstof injektion moderarterie neointima endotel neurobiologi
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