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Bioengineering

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JoVE Journal Bioengineering
Hurtig antistof glycoengineering i kinesiske hamster ovarieceller
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Hurtig antistof glycoengineering i kinesiske hamster ovarieceller

Article DOI: 10.3791/63872-v • 06:53 min • June 2nd, 2022
June 2nd, 2022 •
*1,2, *1,3, 1,4, 5, 5, 4, 1,2, 1
1Department of Chemical Engineering, Imperial College London, 2Imperial College Centre for Synthetic Biology, Imperial College London, 3BioPharm Process Research, GlaxoSmithKline Research and Development, 4Department of Life Science, Imperial College London, 5School of Chemical & Bioprocess Engineering, University College Dublin
* These authors contributed equally

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Glykosyleringsmønsteret for et antistof bestemmer dets kliniske ydeevne, således at industrielle og akademiske bestræbelser på at kontrollere glykosylering vedvarer. Da typiske glykoengineeringskampagner er tids- og arbejdskrævende, ville genereringen af en hurtig protokol til at karakterisere virkningen af glykosyleringsgener ved hjælp af forbigående hæmning vise sig nyttig.

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