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Undersøgelse af patogenesen af MYH7-mutationenGly823Glu i familiær hypertrofisk kardiomyopati ved hjælp af en musemodel…
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Genetics
Genetics
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Undersøgelse af patogenesen af MYH7-mutationen Gly823Glu i familiær hypertrofisk kardiomyopati ved hjælp af en musemodel
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Article
DOI:
10.3791/63949-v
•
03:45 min
•
August 8th, 2022
Undersøgelse af patogenesen af MYH7-mutationen Gly823Glu i familiær hypertrofisk kardiomyopati ved hjælp af en musemodel
August 8th, 2022
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Yu Xia*1,2, Jinlin Hu*3, Xiang Li4, Shuang Zheng4, Ge Wang1,2, Songtao Tan1,2, Zengxiao Zou1,2, Qiong Ling2,5, Fenghua Yang4, Xiaoping Fan1,2
1Department of Cardiovascular Surgery, Guangdong Provincial Hospital of Traditional Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 2The Second Clinical College of Guangzhou University of Chinese Medicine, 3Department of Cardiovascular Surgery, The First Affiliated Hospital, Jinan University, 4Guangdong Provincial Key Laboratory of Laboratory Animals, Guangdong Laboratory Animals Monitoring Institute, 5Department of Anesthesiology, Guangdong Provincial Hospital of Chinese Medicine, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine
* These authors contributed equally
Chapters
Summary
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Baseret på den familiære arvelige kardiomyopatifamilie, der findes i vores kliniske arbejde, skabte vi en C57BL/6N-musemodel med en punktmutation (G823E) ved musen MYH7-locus gennem CRISPR/Cas9-medieret genomteknik for at verificere denne mutation.