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Afinidade celular da emulsão estabilizada por partículas para aumentar a internalização de antígenos

Article DOI: 10.3791/64406-v • 10:06 min • September 2nd, 2022
September 2nd, 2022 •
*1,2,3, *3,4, 3,4, 3, 1,2
1Graduate School of Bio-Applications and Systems Engineering, Tokyo University of Agriculture and Technology, 2Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, 3State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 4University of Chinese Academy of Sciences
* These authors contributed equally

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Para projetar racionalmente adjuvantes eficientes, desenvolvemos emulsão de Pickering estabilizada por nanopartículas poli-láticas-co-glicólicas (PNPE). O PNPE possuía maciez única e uma interface hidrofóbica para contato celular potente e oferecia carga de antígenos de alto conteúdo, melhorando a afinidade celular do sistema de entrega às células apresentadoras de antígenos e induzindo a internalização eficiente de antígenos.

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Bioengenharia Edição 187
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