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JoVE Journal Cancer Research
Translationele orthotopische modellen van glioblastoom multiforme
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Translationele orthotopische modellen van glioblastoom multiforme

Article DOI: 10.3791/64482-v • 07:37 min • February 17th, 2023
February 17th, 2023 •
1, 1, 1
1Center for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, National Cancer Institute

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Hier beschrijven we een preklinisch orthotopisch muismodel voor GBM, vastgesteld door intracraniële injectie van cellen afgeleid van genetisch gemanipuleerde muismodeltumoren. Dit model toont de ziektekenmerken van menselijke GBM. Voor translationele studies wordt de hersentumor van de muis gevolgd door in vivo MRI en histopathologie.

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