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Journal / Cancer Research / 开发用于对程序性死亡配体 1 表达进行成像的 68镓标记的 D 肽 PET…
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开发用于对程序性死亡配体 1 表达进行成像的 68镓标记的 D 肽 PET 示踪剂
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开发用于对程序性死亡配体 1 表达进行成像的 68镓标记的 D 肽 PET 示踪剂

Article DOI: 10.3791/65047-v • 09:06 min • February 3rd, 2023
February 3rd, 2023 •
*1, *2, 1, 2, 2, 4, *2,3, *3, *1, *2
1Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, 2State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 3Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, 4Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
* These authors contributed equally

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本研究开发了一种非侵入性和实时方法，基于[68Ga] D-十二肽拮抗剂的正电子发射断层成像，评估程序性死亡配体1在全身的分布。与传统的免疫组化相比，该技术具有优势，并提高了识别将从免疫检查点阻断疗法中受益的合适患者的效率。

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癌症研究，第 192 期，程序性死亡配体 1 表达，免疫检查点阻断疗法，PD-1，PD-L1 抑制剂，肿瘤细胞，免疫组化 （IHC），正电子发射断层扫描 （PET），放射性标记示踪剂，右旋 （D） 肽，蛋白水解耐药性，代谢半衰期，68Ga 标记的 PD-L1 靶向 D 肽，D-十二肽拮抗剂 （DPA），荷瘤小鼠，稳定性，成像能力
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