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JoVE Journal Cancer Research
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Udvikling af et 68galliummærket D-peptid PET-sporstof til billeddannelse af programmeret dødsligand 1-ekspression

Article DOI: 10.3791/65047-v • 09:06 min • February 3rd, 2023
February 3rd, 2023 •
*1, *2, 1, 2, 2, 4, *2,3, *3, *1, *2
1Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, 2State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 3Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, 4Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
* These authors contributed equally

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Denne undersøgelse udviklede en ikke-invasiv og realtidsmetode til evaluering af fordelingen af programmeret dødsligand 1 i hele kroppen baseret på positronemissionstomografisk billeddannelse af [68Ga] D-dodecapeptidantagonist. Denne teknik har fordele i forhold til konventionel immunhistokemi og forbedrer effektiviteten af at identificere passende patienter, der vil drage fordel af immunkontrolpunktblokadebehandling.

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Kræftforskning udgave 192 programmeret dødsligand 1-ekspression immunkontrolpunktblokadeterapi PD-1 PD-L1-hæmmere tumorceller immunhistokemi (IHC) positronemissionstomografi (PET) radioaktivt mærkede sporstoffer dextrorotære (D)-peptider proteolytisk resistens metaboliske halveringstider 68Ga-mærket PD-L1-målrettet D-peptid D-dodecapeptidantagonist (DPA) tumorbærende mus stabilitet billeddannelsesevne
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