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JoVE Journal Bioengineering
Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
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Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Article DOI: 10.3791/65147-v • 07:44 min • May 12th, 2023
May 12th, 2023 •
*1, *2, 1, 3, 2, 1, 2, 1,4
1Department of Bioengineering, Rice University, 2Particles for Humanity, 3IMPACT Technology Development, 4Department of Chemistry, Rice University
* These authors contributed equally

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Summary
Automatic Translation

This method describes the encapsulation of the rabies antigen into biodegradable polymeric microparticles with structural and material properties that enable pulsatile release after a predetermined delay. Enzyme-linked immunosorbent assay (ELISA) assessment of the antigen retrieved from the particle core confirms the presence of intact trimeric rabies virus glycoprotein through particle fabrication.

Tags

Pulsatile Polymeric Microparticles Rabies Antigen Multiple Dose Vaccines Single Injection Access Challenges Native Immunity Vaccination Schedules Fatal Disease Repeated Vaccine Injections Complete Vaccine Regimen Adherence Platform Technology Diverse Therapeutics Prophylactics 3D-printed Master Mold Vacuum Chamber Trichlorosilane PDMS Prepolymer Base Curing Agent
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