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Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)
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Murine Colitis Modeling using Dextran Sulfate Sodium (DSS)

Article DOI: 10.3791/1652-v • 08:40 min • January 19th, 2010
January 19th, 2010 •
1, 2, 2
1Department of Cancer Biology, Vanderbilt University, 2Departments of Medicine and Cancer Biology, Vanderbilt University

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Dextran sulfate sodium (DSS) administered in the drinking water is an established murine inflammatory injury model of acute colitis. This protocol outlines the method for DSS treatment and the preparation of tissues.

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Murine Colitis Modeling Dextran Sulfate Sodium (DSS) Colitis Ulcerative Colitis Crohn's Disease Crohn's Colitis Abdominal Pain Distention Malabsorption Diarrhea Hematochezia Mucus In Stool Environment Genetics Epithelial Barrier Dysfunction Inflammatory Bowel Disease Animal Models Of Colitis Low-molecular Weight Dextran Sodium Sulfate (DSS) Epithelial Damage Inflammatory Response Acute Injury Chronic Inflammatory Diseases 3% DSS In Drinking Water Weight Loss Bloody Stools Diarrhea Euthanized Necropsy Dissected Colons Microscopic Analysis Macroscopic Analysis
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