Ole Isacson: Development of New Therapies for Parkinson's Disease

Published 4/29/2007
5 Comments
  CITE THIS  SHARE 
Biology

You must be subscribed to JoVE to access this content.

Fill out the form below to receive a free trial:

Welcome!

Enter your email below to get your free 10 minute trial to JoVE!





By clicking "Submit," you agree to our policies.

 

Summary

Ole Isacson gives a concise overview of Parkinsons's disease, its causes, therapeutic strategies, and advances in Parkinson's research.

Cite this Article

Copy Citation

Isacson, O. Ole Isacson: Development of New Therapies for Parkinson's Disease. J. Vis. Exp. (3), e189, doi:10.3791/189 (2007).

Abstract

References

  1. Chung, C. Y., Seo, H., Sonntag, K. C., Brooks, A., Lin, L., Iasacson, O. Cell type specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability. Hum. Mol. Genet. 14, 1709-1725 (2005).
  2. Mendez, I., Sanchez-Pernaute, R., Cooper, O., Vinuela, A., Ferrari, D., Bjoerklund, L., Dagher, A., Isacson, O. Cell type analysis of fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease. Brain. 128, (7), 1498-1510 (2005).
  3. Cooper, O., Isacson, O. Intrastiatal Transforming Growth Factor Delivery to a Model of Parkinson's Disease Induces Proliferation and Migration of Endogenous Adult Neural Progenitor Cells without Differentiation into Dopaminergic Neurons. J. Neurosci. 24, (41), 8924-8931 (2004).
  4. Sanchez-Pernaute, R., Ferree, A., Cooper, O., Yu, M., Brownell, A. L., Isacson, O. Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat mod of Parkinson's disease. Journal of Neuroinflammation. (2004).
  5. Isacson, O. The production and use of cells as therapeutic agents in neurodegenerative diseases. Lancet Neurology. 2, (7), 417-424 (2003).

Comments

5 Comments

  1. nice

    Reply
    Posted by: Anonymous
    July 22, 2009 - 3:13 AM
  2. i know you want to see my comment "very interesting" so here it is : very interesting

    Reply
    Posted by: Anonymous
    October 14, 2009 - 5:04 PM

Post a Question / Comment / Request

You must be signed in to post a comment. Please or create an account.

Video Stats