Ole Isacson: développement de nouvelles thérapies pour la maladie de Parkinson


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Ole Isacson donne un aperçu concis de la maladie de Parkinson est, ses causes, les stratégies thérapeutiques et les progrès de la recherche sur le Parkinson.

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Isacson, O. Ole Isacson: Development of New Therapies for Parkinson's Disease. J. Vis. Exp. (3), e189, doi:10.3791/189 (2007).

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  1. Chung, C. Y., Seo, H., Sonntag, K. C., Brooks, A., Lin, L., Iasacson, O. Cell type specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability. Hum. Mol. Genet. 14, 1709-1725 (2005).
  2. Mendez, I., Sanchez-Pernaute, R., Cooper, O., Vinuela, A., Ferrari, D., Bjoerklund, L., Dagher, A., Isacson, O. Cell type analysis of fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease. Brain. 128, (7), 1498-1510 (2005).
  3. Cooper, O., Isacson, O. Intrastiatal Transforming Growth Factor Delivery to a Model of Parkinson's Disease Induces Proliferation and Migration of Endogenous Adult Neural Progenitor Cells without Differentiation into Dopaminergic Neurons. J. Neurosci. 24, (41), 8924-8931 (2004).
  4. Sanchez-Pernaute, R., Ferree, A., Cooper, O., Yu, M., Brownell, A. L., Isacson, O. Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat mod of Parkinson's disease. Journal of Neuroinflammation. (2004).
  5. Isacson, O. The production and use of cells as therapeutic agents in neurodegenerative diseases. Lancet Neurology. 2, (7), 417-424 (2003).



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    July 22, 2009 - 3:13 AM
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    October 14, 2009 - 5:04 PM

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