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Journal / Neuroscience / Muismodellen van periventriculaire leukomalacie
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JoVE Journal Neuroscience
Muismodellen van periventriculaire leukomalacie
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Muismodellen van periventriculaire leukomalacie

Article DOI: 10.3791/1951-v • 06:24 min • May 18th, 2010
May 18th, 2010 •
1, 1, 1
1Department of Cell Biology and Human Anatomy Institute for Pediatric Regenerative Medicine School of, University of California, Davis

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We muismodellen vastgesteld van periventriculaire leukomalacie (PVL), de overheersende hersenletsel bij premature baby's gekenmerkt door periventriculaire witte stof afwijkingen. Hypoxie / ischemie met / zonder systemische infectie zijn de voornaamste oorzaken van PVL. Eenzijdige carotis ligatie en hypoxie blootstelling met / zonder lipopolysaccharide injectie zorgt voor PVL-achtige laesies in de P6 muizen.

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Jove Neuroscience hersenen muis witte stof letsel oligodendrocyt periventriculaire leukomalacie
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