Building a Better Mosquito: Identifying the Genes Enabling Malaria and Dengue Fever Resistance in A. gambiae and A. aegypti Mosquitoes

Published 7/04/2007
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Biology
 

Summary

In this interview, George Dimopoulos focuses on the physiological mechanisms used by mosquitoes to combat Plasmodium falciparum and dengue virus infections. Explanation is given for how key refractory genes, those genes conferring resistance to vector pathogens, are identified in the mosquito and how this knowledge can be used to generate transgenic mosquitoes that are unable to carry the malaria parasite or dengue virus.

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Dimopoulos, G. Building a Better Mosquito: Identifying the Genes Enabling Malaria and Dengue Fever Resistance in A. gambiae and A. aegypti Mosquitoes. J. Vis. Exp. (5), e233, doi:10.3791/233 (2007).

Abstract

In this interview, George Dimopoulos focuses on the physiological mechanisms used by mosquitoes to combat Plasmodium falciparum and dengue virus infections. Explanation is given for how key refractory genes, those genes conferring resistance to vector pathogens, are identified in the mosquito and how this knowledge can be used to generate transgenic mosquitoes that are unable to carry the malaria parasite or dengue virus.

Disclosures

The authors have nothing to disclose.

Comments

2 Comments

  1. HOW CAN I DOWNLOAD

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    Posted by: Anonymous
    November 2, 2007 - 10:47 AM
  2. Is there any phylogenetic relationship between aedes and anopheles mosquito?

    Reply
    Posted by: Anonymous
    March 16, 2009 - 11:31 AM

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