ALS - Motor Neuron Disease: Mechanism and Development of New Therapies


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Jeffrey D. Rothstein speaks about the pathology and mechanisms underlying amyotrophic lateral sclerosis or ALS, advances in ALS research, and current strategies towards the development of therapies.

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Rothstein, J. D. ALS - Motor Neuron Disease: Mechanism and Development of New Therapies. J. Vis. Exp. (6), e245, doi:10.3791/245 (2007).



The authors have nothing to disclose.



  1. My father has been diagnosed with ALS.  His symptoms began about one year ago.  On Jan. 5, ²008, he went into respiratory arrest, but through CPR & shock. he survived.  He is 8² years old, but has always been in great health & is a strong man.  After 9 weeks at the UAMS, he has been home for almost 5 months & is doing very well.  He lifts weights everyday, dŒs leg excercises, & various other excercises to maintain his strength.  He has a good outlook on his disease, he is totally coherant and dŒs everything we can think of to slow down the progression of this disease & maintain a quality of life. He has an appt. with an ALS specialist on Sept. 8, ²008.  I would like to know as much about this disease as possible, especially the new developments with stem cell research.  I have researched this very thoroughly already, but I wasn't aware until yesterday that there may be hope through stem cell research. Please send me anything informative that you may have.  I have a lot of questions for the dr. at the appt. scheduled, but I would like to be more informed. Thank you very much, Janet Dean  (daughter & primary caregiver)  

    Posted by: Anonymous
    August 3, 2008 - 2:56 PM
  2. Respected sir,
        My mother is suffering from ALS Motor for the past 4 months.she is 53  years old
    She is under the treatment but it dŒsn't show any progress 
    in her health.As the early symptom she seemed like affected 
    psychologicallyas she would laugh or cry with no reason,
    but now after treatment Now she can't able to speak clearly and she feels pain in her
    right hand when she do work.She finds difficult to swallow the
    food.Could you please say me the treatment and can she become
    normal again.
        Is this disease is completely curable?
        I am waiting your reply


    Posted by: karthikyan c.
    February 2, 2009 - 6:23 AM
  3. is there any development on the research of treatment of MND? How damage in MND can be minmized?

    Posted by: Anonymous
    February 7, 2009 - 1:40 AM
  4. Actually, there are ways to solve als which develops as the logical result of things going on in a person's life.

    By adjusting what is going on with the factors and patterns that underlie the development of als, a person can solve the problem and heal.

    All the mouse studies, gene studies, drug studies and the rest of the medical work being done to solve als, while possibly entertaining and marginally useful, ignore the key issues and are mostly a waste of time.

    Posted by: Anonymous
    August 6, 2010 - 3:11 PM

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