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An Alternant Method to the Traditional NASA Hindlimb Unloading Model in Mice

Article DOI: 10.3791/2467-v • 09:50 min • March 10th, 2011
March 10th, 2011 •
1, 2, 1,2
1Physical Therapy Department, University of Missouri, Columbia, 2Biomedical Sciences Department, University of Missouri, Columbia

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We developed an alternant hindlimb unloading model in mice. The primary advantage of our hindlimb unloading tail-ring method over the conventional Morey-Holton tail-traction technique is a simple straightforward procedure that minimizes stress upon the animal.

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Alternant Method Traditional NASA Hindlimb Unloading Model Mice Morey-Holton Hindlimb Unloading Disuse-atrophy Rodents Gold-standard Morey-Holton HU Tail-traction Technique Female Mice Recovery From HU Normal Cage Ambulation Weight-bearing Controls Tail Ring Inter-vertebral Disc Space Soleus Atrophy Adrenal Mass
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