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Journal / Immunology and Infection / HLA-Ig celle in base Antigen Presenting…
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Immunology and Infection

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JoVE Journal Immunology and Infection
HLA-Ig celle in base Antigen Presenting artificiale per Efficiente Ex vivo Estensione dei diritti dell'uomo e CTL
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HLA-Ig celle in base Antigen Presenting artificiale per Efficiente Ex vivo Estensione dei diritti dell'uomo e CTL

Article DOI: 10.3791/2801-v • 07:19 min • April 11th, 2011
April 11th, 2011 •
1,2, 3,4, 3,4
1Immunology Graduate Program, Johns Hopkins University, 2Department of Internal Medicine, Far-Eastern Memorial Hospital, 3Department of Pathology, Johns Hopkins University, 4Institute of Cell Engineering, Johns Hopkins University

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Un nuovo metodo DC indipendente per l'induzione e l'espansione di antigene-specifica delle cellule T è descritta. HLA-A2 Ig Cellule artificiali basati Antigen Presenting (aAPC) vengono caricati con HLA-A2 peptidi limitato ad ampliare in modo efficace CTL di specificità antigenica diversi. Questa tecnologia ha un grande potenziale per CTL-immunoterapia adottiva.

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Immunologia Numero 50 immunoterapia terapia cellulare adottiva T cellule T CD8 + HLA-A2-Ig CMV aAPC DC
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