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Journal / Immunology and Infection / HLA-IG Baserat Konstgjord antigenpresenterande…
JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection
HLA-IG Baserat Konstgjord antigenpresenterande celler för effektiv Ex vivo Utbyggnad av mänskliga CTL
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HLA-IG Baserat Konstgjord antigenpresenterande celler för effektiv Ex vivo Utbyggnad av mänskliga CTL

Article DOI: 10.3791/2801-v • 07:19 min • April 11th, 2011
April 11th, 2011 •
1,2, 3,4, 3,4
1Immunology Graduate Program, Johns Hopkins University, 2Department of Internal Medicine, Far-Eastern Memorial Hospital, 3Department of Pathology, Johns Hopkins University, 4Institute of Cell Engineering, Johns Hopkins University

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En ny DC oberoende metod för induktion och expansion av antigen-specifika T-celler beskrivs. HLA A2-Ig bygger konstgjorda antigenpresenterande celler (aAPC) är laddade med HLA-A2 begränsad peptider för att effektivt utöka CTL av olika antigenspecificitet. Denna teknik innebär stora möjligheter för CTL-baserade adoptiv immunterapi.

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Immunologi 50 immunterapi adoptiv T cellterapi CD8 + T-celler HLA-A2-IG CMV aAPC DC
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