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Journal / Immunology and Infection / Verimli HLA-Ig Tabanlı Yapay antijen sunan…
JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection
Verimli HLA-Ig Tabanlı Yapay antijen sunan hücrelerin Ex vivo Genleşme
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Verimli HLA-Ig Tabanlı Yapay antijen sunan hücrelerin Ex vivo Genleşme

Article DOI: 10.3791/2801-v • 07:19 min • April 11th, 2011
April 11th, 2011 •
1,2, 3,4, 3,4
1Immunology Graduate Program, Johns Hopkins University, 2Department of Internal Medicine, Far-Eastern Memorial Hospital, 3Department of Pathology, Johns Hopkins University, 4Institute of Cell Engineering, Johns Hopkins University

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Antijen-spesifik T hücrelerinin indüksiyon ve genişleme için yeni bir DC bağımsız bir yöntem açıklanmıştır. HLA-A2-Ig tabanlı yapay Antijen sunan hücreler (aAPC), HLA-A2 verimli farklı antijen özgüllüğü CTL genişletmek için kısıtlı peptitler ile yüklenir. Bu teknoloji tabanlı CTL evlatlık immünoterapi için büyük bir potansiyele sahiptir.

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İmmünoloji Sayı 50 immünoterapi evlat edinen T hücre tedavisi CD8 + T hücreleri HLA-A2-Ig CMV aAPC DC
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