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Neuroscience

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JoVE Journal Neuroscience
Detectie van neuritische plaques in de ziekte van Alzheimer Mouse Model
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Detectie van neuritische plaques in de ziekte van Alzheimer Mouse Model

Article DOI: 10.3791/2831-v • 06:02 min • July 26th, 2011
July 26th, 2011 •
*1, *1, 1
1Department of Neuroscience, The University of British Columbia
* These authors contributed equally

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Een van de pathologische kenmerken van AD is de vorming van amyloïde eiwit β positief neuritische plaques. In dit protocol beschrijven we twee methoden om seniele plaques op te sporen in transgene muizen die model AD: immunohistochemische detectie met behulp van de ABC-en DAB-methode en fluorescerende detectie met behulp van thioflavin S kleuringsmethode.

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Neurowetenschappen de ziekte van Alzheimer neuritische plaques amyloïde eiwit β APP transgene muis
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