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GABA-activated Single-channel and Tonic Currents in Rat Brain Slices
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GABA-activated Single-channel and Tonic Currents in Rat Brain Slices

Article DOI: 10.3791/2858-v • 10:00 min • July 17th, 2011
July 17th, 2011 •
1, 1, 1
1Department of Neuroscience, Uppsala University, Sweden

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We use the patch-clamp technique to measure GABA-activated single-channel currents (GABAA channels, GABAA receptors) and the synaptic and tonic currents they generate in neurons. Activation of the channels decreases neuronal excitability in health and disease 1,2,3,4.

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GABA-activated Single-channel Tonic Currents Rat Brain Slices GABAA Channels Synapses Phasic Currents Chloride Channel Pentameric GABA-gated Channel Channel Subunits Families Alphas Betas Functional Channel Sub-type Specific Neuronal Inhibition Pharmacological Agents Patch-clamp Technique Functional Properties Hippocampal Brain Slices Single-channel Currents Whole-cell Currents GABA Concentrations Drugs Intra And Extracellular Factors
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