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Immunology and Infection

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JoVE Journal Immunology and Infection
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Article DOI: 10.3791/3154-v • 10:28 min • December 15th, 2011
December 15th, 2011 •
1, 1, 2, 3, 2, 2
1Division of Microbiology, Tulane National Primate Research Center, 2Division of Comparative Pathology, Tulane National Primate Research Center, 3Division of Veterinary Medicine, Tulane National Primate Research Center

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Summary
Automatic Translation

Dermatitis herpetiformis (DH) is a chronic inflammatory condition characterized by an autoimmune reaction between IgA and epidermal transglutaminase (eTG). DH develops in a very small portion of gluten-sensitive and/or celiac patients. The results of this study indicate that DH can also develop in a rhesus monkey host with symptoms of idiopatic dermatitis.

Tags

Epidermal Transglutaminase IgA Antibodies Tissue Transglutaminase 2 Antibodies Rhesus Dermatitis Celiac Disease Autoimmune Response Small Intestinal Wall Gliadin Peptides Dermatitis Herpetiformis Confocal Microscopy Examination Biopsy Samples Rhesus Macaques
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