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Immunology and Infection

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Application of a Mouse Ligated Peyer’s Patch Intestinal Loop Assay to Evaluate Bacterial Uptake by M cells

Article DOI: 10.3791/3225-v • 06:00 min • December 17th, 2011
December 17th, 2011 •
1, 1, 1
1Laboratory for Epithelial Immunobiology, RIKEN Research Center for Allergy and Immunology

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Summary
Automatic Translation

M cells in a specialized follicle-associated epithelium covering Peyer’s patches play an important role for the mucosal immunosurveillance in gut-associated lymphoid tissue. Here we described the evaluation method for bacterial transcytosis by M cells in vivo. This method provides a method to understand M-cell function in the immune system.

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Mouse Ligated Peyer's Patch Intestinal Loop Assay Bacterial Uptake M Cells Gut-associated Lymphoid Tissue (GALT) Mucosal Immune Response Mucosal Antigens Antigen Transcytosis Specialized Epithelial M Cells Macromolecular Transcytosis Antigen-specific Mucosal Immune Responses Glycoprotein 2 (Gp2) Enterocytes Commensal Bacteria Pathogenic Bacteria
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