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Udvikling af en ensidigt-læderede 6-OHDA-musemodellen af ​​Parkinsons sygdom
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Udvikling af en ensidigt-læderede 6-OHDA-musemodellen af ​​Parkinsons sygdom

Article DOI: 10.3791/3234-v • 10:09 min • February 14th, 2012
February 14th, 2012 •
1, 1, 1
1Centre for Neurobiology of Stress, Dept Biological Sciences, University of Toronto at Scarborough

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En protokol til udførelse unilaterale 6-OHDA-læsioner i den mediale forhjernen bundtet i mus er beskrevet. Denne fremgangsmåde har en lav dødelighed (13,3%) med 89% af de overlevende dyr, som udviser> 95% tab af striatal dopamin og 90,63 ± -4,02% ipsiversive roterende forspænding mod den side af læsionen.

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Medicin mus 6-OHDA Parkinsons sygdom mediale forhjernen bundle ensidige
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