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CYP2D6 Animal Model
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CYP2D6 Animal Model: Hur Framkalla Autoimmun hepatit hos möss

Article DOI: 10.3791/3644-v • 09:03 min • February 3rd, 2012
February 3rd, 2012 •
1, 1, 1
1Pharmazentrum Frankfurt / ZAFES, Goethe University Hospital Frankfurt

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Infektion av möss med ett adenovirus som uttrycker den viktigaste humana autoantigen cytokrom P450 2D6 (hCYP2D6) som erkänns av sera från patienter som lider av typ 2 autoimmun hepatit resulterar i en ihållande form av autoimmun-medierad leversjukdom som kännetecknas av omfattande hepatit, fibros och generering av en CYP2D6 -specifikt immunsvar.

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Medicin Utgåva 60 autoimmunitet lever autoantigen fibros perfusionen
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