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Mame Modeller for 4D live-cell imaging af tumor
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Mame Modeller for 4D live-cell imaging af tumor: mikromiljø interaktioner, Impact malignt Progression

Article DOI: 10.3791/3661-v • 08:27 min • February 17th, 2012
February 17th, 2012 •
1, 1, 1, 1,2, 1,2, 1,2
1Department of Pharmacology, Wayne State University, 2Barbara Ann Karmanos Cancer Institute, Wayne State University

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Vi har udviklet 3D cokultur modeller for live-cell imaging i real-tid interaktioner mellem bryst tumorceller og andre celler i deres mikromiljø, der påvirker progression til en invasiv fænotype. Disse modeller kan tjene som prækliniske skærme for lægemidler til at målrette paracrine-inducerede proteolytiske, chemokin / cytokin og kinase veje involveret i invasiv.

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Medicin Immunology bryst cancer ekstracellulær matrix invasion proteolyse tumormikromiljøet
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