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JoVE Journal Bioengineering
Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
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Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Article DOI: 10.3791/3958-v • 11:08 min • June 22nd, 2012
June 22nd, 2012 •
*1,2,3,4, *1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4
1Department of Pediatrics, Emory University School of Medicine, 2Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 3Aflac Cancer Center and Blood Disorders Service of Children's Healthcare of Atlanta, 4Winship Cancer Institute of Emory University
* These authors contributed equally

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A method to culture an endothelial cell monolayer throughout the entire inner 3D surface of a microfluidic device with microvascular-sized channels (<30 μm) is described. This in vitro microvasculature model enables the study of biophysical interactions between blood cells, endothelial cells, and soluble factors in hematologic diseases.

Tags

Microfluidics Endothelialized Microfluidics Microvascular Interactions Hematologic Diseases Microfabrication Techniques Biological Experiments Biochemical Experiments Micro- And Nanoscales Hematologic Processes Blood Cell Deformability Blood Cell Aggregation Microvascular Blood Flow Blood Cell-endothelial Cell Interactions Cultured Endothelial Cells Microcirculation Biophysical Pathophysiology
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