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Immunology and Infection

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JoVE Journal Immunology and Infection
An In vitro Co-infection Model to Study Plasmodium falciparum-HIV-1 Interactions in Human Primary Monocyte-derived Immune Cells
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An In vitro Co-infection Model to Study Plasmodium falciparum-HIV-1 Interactions in Human Primary Monocyte-derived Immune Cells

Article DOI: 10.3791/4166-v • 07:40 min • August 15th, 2012
August 15th, 2012 •
1, 1, 1, 1, 1
1Infectious Disease Research Center, CHUL (CHUQ), Quebec City, Quebec, Canada

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Summary
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We have developed an in vitro malaria-HIV-1 co-infection model to study the impact of Plasmodium falciparum on the HIV-1 replicative cycle in human primary monocyte-derived macrophages. This versatile system can easily be adapted to other primary cell types susceptible to HIV-1 infection.

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In Vitro Co-infection Model Plasmodium Falciparum HIV-1 Interactions Human Primary Monocyte-derived Immune Cells Malaria HIV-1 Co-infections Disease Progression Transmission Immunological Mechanisms Soluble Malarial Antigens HIV-1 Infection Reactivation Immune Cells P. Falciparum Schizont Stage Parasites Peripheral Blood Mononuclear Cells
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