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Journal / Immunology and Infection / Brug af BLT Humaniseret Mouse som en stamcelle…
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Immunology and Infection

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JoVE Journal Immunology and Infection
Brug af BLT Humaniseret Mouse som en stamcelle baseret genterapi tumormodel
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Brug af BLT Humaniseret Mouse som en stamcelle baseret genterapi tumormodel

Article DOI: 10.3791/4181-v • 06:59 min • December 18th, 2012
December 18th, 2012 •
1,2,3, 1,2, 1,2, 1,2, 4, 4, 1,2,3, 1,2,5
1Department of Medicine, Division of Hematology-Oncology, David Geffen School of Medicine at UCLA, 2UCLA AIDS Institute, 3Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA, 4Department of Medical and Molecular Pharmacology, David Geffen School of Medicine at UCLA, 5Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA

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Generering og karakterisering af tumorspecifikke T-celler under anvendelse af humaniserede mus er beskrevet her. Humant thymisk væv og genetisk modificerede humane hæmatopoietiske stamceller transplanteres ind immunkompromitterede mus. Dette resulterer i rekonstituering af et manipuleret humant immunsystem muliggør in vivo undersøgelse af anti-tumor immunrespons.

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Cancer Biology Stem Cell Biology Immunology Biomedical Engineering Medicine Bioengineering Genetics onkologi Humaniserede mus stamcelletransplantation stamceller, T-celler cancer dyremodel
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