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A Novel Bayesiaanse Change-point algoritme voor Genoom-brede analyse van diverse ChIPseq Data Types
 
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A Novel Bayesiaanse Change-point algoritme voor Genoom-brede analyse van diverse ChIPseq Data Types

Article DOI: 10.3791/4273-v 12:39 min December 10th, 2012
December 10th, 2012

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Summary

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Onze Bayesiaanse Change Point (BCP) algoritme is gebaseerd op state-of-the-art ontwikkelingen in het modelleren change-punten via Hidden Markov Models en past deze toe op chromatine immunoprecipitatie sequencing (ChIPseq) data-analyse. BCP presteert goed in zowel brede en punctata data types, maar blinkt uit in nauwkeurig identificeren van robuuste, reproduceerbare eilanden van diffuse histon verrijking.

Tags

Genetica Bio-informatica Genomics Moleculaire Biologie Celbiologie Immunologie chromatine immunoprecipitatie chip-Seq histon modificaties segmentatie Bayesiaanse Hidden Markov Models epigenetica
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