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Kvantitativ analyse af kromatin Proteomes i Disease
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Kvantitativ analyse af kromatin Proteomes i Disease

Article DOI: 10.3791/4294-v • 08:11 min • December 28th, 2012
December 28th, 2012 •
1, 1, 1, 1, 1,2,3, 1,4
1Department of Anesthesiology, David Geffen School of Medicine at UCLA, 2Department of Medicine, David Geffen School of Medicine at UCLA, 3Department of Physiology, David Geffen School of Medicine at UCLA, 4Department of Internal Medicine, Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah

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Fremskridt inden massespektrometri har tilladt high throughput analyse af proteinekspression og ændringen i en lang række væv. Kombineret med subcellulær fraktionering og sygdomsmodeller, kvantitativ massespektrometri og bioinformatik kan afsløre nye egenskaber i biologiske systemer. Fremgangsmåden beskrevet heri analyseres chromatin-associerede proteiner i tilfælde af hjertesygdomme og let anvendes til andre

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Medicin Molecular Biology Immunology Genetics Genomics fysiologi Protein DNA Kromatin kardiovaskulær sygdom proteomics massespektrometri
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