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Journal / Medicine / Neo-Islet formationen i leveren af ​​diabetiske…
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Neo-Islet formationen i leveren af ​​diabetiske mus med Hjælper-afhængig adenovirusvektor-medieret genoverførsel
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Neo-Islet formationen i leveren af ​​diabetiske mus med Hjælper-afhængig adenovirusvektor-medieret genoverførsel

Article DOI: 10.3791/4321-v • 16:59 min • October 10th, 2012
October 10th, 2012 •
1,2, 1,2,3, 1,2,3
1Department of Medicine, Baylor College of Medicine, 2Division of Diabetes, Endocrinology & Metabolism, Diabetes & Endocrinology Research Center, Baylor College of Medicine, 3Department of Molecular & Cellular Biology, Baylor College of Medicine

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Vi beskriver hepatisk neo-ø-dannelse i STZ (streptozotocin)-inducerede diabetiske mus ved genoverførsel af Neurogenin3 (Ngn3) og betacellulin (BTC) under anvendelse af hjælper-afhængige adenovirusvektor (HDAd) og tilbageførsel af hyperglykæmi. Vores metode tager fordele hjælper-afhængige adenovirusvektorer med deres meget effektiv in vivo transduktion og den langvarige genekspression.

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Medicin genetik fysiologi Genterapi Neurogenin3 betacellulin hjælper-afhængige adenovirusvektorer type 1 diabetes ø Neogenesis
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