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Immunology and Infection

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JoVE Journal Immunology and Infection
Real-time Billeddannelse af heterotypisk blodplade-neutrophile interaktioner på aktiveret endotel Under vaskulær inflammation og thrombedannelse i levende mus
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Real-time Billeddannelse af heterotypisk blodplade-neutrophile interaktioner på aktiveret endotel Under vaskulær inflammation og thrombedannelse i levende mus

Article DOI: 10.3791/50329-v • 11:18 min • April 2nd, 2013
April 2nd, 2013 •
1, 1, 1,2
1Department of Pharmacology, University of Illinois at Chicago, 2Department of Anesthesiology, University of Illinois at Chicago

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Her rapporterer vi en eksperimentel teknik til fluorescens intravital mikroskopi at visualisere heterotypiske blodplade-neutrophile interaktioner på aktiveret endotel under vaskulær inflammation og thrombedannelse i levende mus. Denne mikroskopisk teknologi vil være værdifuldt at undersøge den molekylære mekanisme af vaskulær sygdom og afprøve farmakologiske midler under patofysiologiske betingelser.

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Immunologi Medicine Cellular Biology Molecular Biology Inflammation Hematology Neutrofiler Mikroskopi Video Thrombosis blodpladeaktivering blodpladeaggregering intravital mikroskopi blodplader neutrofile rullende adhæsion vaskulær inflammation trombedannelse mus dyremodel
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