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Celledød Associated med Unormal Mitosis Observert av Confocal Imaging in Live-kreftceller
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Celledød Associated med Unormal Mitosis Observert av Confocal Imaging in Live-kreftceller

Article DOI: 10.3791/50568-v • 15:53 min • August 21st, 2013
August 21st, 2013 •
1, 2,3, 4, 4, 5, 1,6, 2,3
1Cancer Research Center, Sheba Medical Center, 2The Neufeld Cardiac Research Institute, Tel-Aviv University, 3Department of Physiology and Pharmacology, Tel-Aviv University, 4Imaging Unit, Sackler Faculty of Medicine, Tel-Aviv University, 5Biotechnology and Cell Signaling, Ecole Superieure de Biotechnologie Strasbourg, 6Department of Human Molecular Genetics and Biochemistry, Tel-Aviv University

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Den cytotoksiske aktiviteten til phenanthridine PJ-34 i kreftceller som gjennomgår mitose ble dokumentert i sanntid ved konfokal levende avbildning. PJ-34 utryddet menneskelig brystkreft MDA-MB-231 celler som ekstra-centrosomes i mitose. I motsetning til normal bi-fokale mitose, ble de ekstra-centrosomes ikke gruppert i de to spindel polene i nærvær av PJ-34.

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Cancer Biology medisin cellebiologi molekylær biologi Biomedical Engineering anatomi fysiologi genetikk Neoplastiske Prosesser pharmacologic Actions live confocal bildebehandling Ekstra-centrosomes clustering / de-clustering Mitotisk Catastrophe celledød PJ-34 hjerteinfarkt mikroskopi bildebehandling
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