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JoVE Journal
Bioengineering

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Nonhuman Primate Lung Decellularization and Recellularization Using a Specialized Large-organ Bioreactor
 

Nonhuman Primate Lung Decellularization and Recellularization Using a Specialized Large-organ Bioreactor

Article DOI: 10.3791/50825-v 16:45 min December 15th, 2013
December 15th, 2013

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Summary

Whole-organ decellularization produces natural biological scaffolds that may be used for regenerative medicine. The description of a nonhuman primate model of lung regeneration in which whole lungs are decellularized and then seeded with adult stem cells and endothelial cells in a bioreactor that facilitates vascular circulation and liquid media ventilation is presented.

Tags

Nonhuman Primate Lung Decellularization Recellularization Large-organ Bioreactor Organ Transplantation Bioartificial Tissue Regeneration Extracellular Matrix (ECM) Autologous Cells Stem/progenitor Cells Scaffold Regeneration Natural ECM Decellularization Process Detergents Salts Enzymes Cellular Material Removal Pulmonary-like Tissue Gas Exchange Rodent Models Nonhuman Primates (NHP) Bioartificial Organ Production Clinical Use NHP Rhesus Macaque
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