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Induksjon av Invasive Transitional Cell blære carcinoma in Immune Intakt Menneskelige MUC1 transgene mus
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Induksjon av Invasive Transitional Cell blære carcinoma in Immune Intakt Menneskelige MUC1 transgene mus: En modell for Immunterapi Development

Article DOI: 10.3791/50868-v • 11:02 min • October 30th, 2013
October 30th, 2013 •
1, 1, 2, 1, 1, 1, 3, 1
1Department of Internal Medicine, Division of Hematology and Oncology, University of California, Davis, 2Comparative Pathology Laboratory, UC Davis School of Veterinary Medicine, University of California, Davis, 3Merck Serono Research, Merck KGaA, Darmstadt, Germany

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Et N-butyl-N-(4-hydroksybutyl) nitrosamin-indusert blærekreft modell ble utviklet i human mucin 1 (MUC1) transgene mus for å teste MUC1-rettet immunterapi. Etter administrering av en MUC1-målrettet peptid vaksine, ble en cytotoksisk T-lymfocytt respons på MUC1 bekreftet ved å måle serum cytokin nivåer og T-celle spesifikke aktivitet.

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Medisin urinblæren Animals genmodifiserte kreftvaksiner Immunterapi forsøk med dyr modeller svulster blærekreft C57BL / 6 mus MUC1 Immunterapi preklinisk modell
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