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Journal / Biology / Mus Genome Engineering Använda Designer nukleaser
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Mus Genome Engineering Använda Designer nukleaser

Article DOI: 10.3791/50930-v • 12:04 min • April 2nd, 2014
April 2nd, 2014 •
1, 2, 2, 1
1Institute of Laboratory Animal Science, University of Zurich, 2Department of Genetics, Cell Biology & Development and Center for Genome Engineering, University of Minnesota

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Designer nukleaser såsom zinkfinger nukleaser (ZFNs) och transkriptionsaktivatorpliknande effektorceller nukleaser (TALENS) kan användas för att modifiera genomet hos mus preimplantatorisk embryon genom att utlösa både icke-homolog ände gå (NHEJ) och homolog rekombination (HR) vägar. Dessa framsteg möjliggöra snabb generering av möss med exakta genetiska modifieringar.

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Genetik Äggcellen mikroinjektion Design nukleaser ZFN TALEN Genome Engineering
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