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Journal / Medicine / Die Produktion von Apolipoprotein C-III-Knockout…
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Die Produktion von Apolipoprotein C-III-Knockout Kaninchen mit Zink-Finger-Nukleasen
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Die Produktion von Apolipoprotein C-III-Knockout Kaninchen mit Zink-Finger-Nukleasen

Article DOI: 10.3791/50957-v • 10:59 min • November 18th, 2013
November 18th, 2013 •
1, 1, 1, 1, 1, 2, 1
1Center for Advanced Models for Translational Sciences and Therapeutics, Department of Internal Medicine, University of Michigan Medical Center, 2Department of Molecular Pathology, University of Yamanashi

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Neueste Entwicklungen in der Gen-Targeting-Tools macht die Produktion von Knockout (KO) Kaninchen möglich. In der vorliegenden Arbeit haben wir einen fünf Apolipoprotein (Apo) C-III KO Kaninchen mit Zink-Finger-Nukleasen (ZFN). Diese Arbeit zeigte, dass ZFN ist eine hocheffiziente Methode, um KO Kaninchen zu produzieren.

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Medizin Apolipoprotein C-III Kaninchen KO Zinkfinger-Nuclease Herz-Kreislauf-Erkrankungen Fettstoffwechsel ApoCIII
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