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Produksjon av Apolipoprotein C-III Knockout Kaniner bruker sink finger nukleaser
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Produksjon av Apolipoprotein C-III Knockout Kaniner bruker sink finger nukleaser

Article DOI: 10.3791/50957-v • 10:59 min • November 18th, 2013
November 18th, 2013 •
1, 1, 1, 1, 1, 2, 1
1Center for Advanced Models for Translational Sciences and Therapeutics, Department of Internal Medicine, University of Michigan Medical Center, 2Department of Molecular Pathology, University of Yamanashi

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Ny utvikling i genet målretting verktøy som gjør produksjonen av knockout (KO) kaniner mulig. I dette arbeidet, genererte vi fem Apolipoprotein (Apo) C-III KO kaniner som bruker sink finger nukleaser (ZFN). Dette arbeidet viser at ZFN er en svært effektiv metode for å produsere KO kaniner.

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Medisin Apolipoprotein C-III kaniner knockout sink finger nuclease hjerte-og karsykdommer lipid metabolisme ApoCIII
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