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JoVE Journal Bioengineering
Sensing af Barrier vævssprængning med en organisk Elektrokemisk Transistor
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Sensing af Barrier vævssprængning med en organisk Elektrokemisk Transistor

Article DOI: 10.3791/51102-v • 11:17 min • February 10th, 2014
February 10th, 2014 •
1, 1, 2, 1, 1
1Department of Bioelectronics, Ecole Nationale Superieure des Mines, 2Research and Exploratory Development Division, Applied Physics Laboratory, Johns Hopkins University

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The Organic Elektrokemisk Transistor er integreret med levende celler og anvendes til at overvåge ion flux på tværs af mave epitelbarriere. I denne undersøgelse blev en stigning i ion-flux, relateret til forstyrrelse af tight junctions induceret ved tilstedeværelsen af ​​calcium chelator EGTA (ethylenglycol-bis (beta-aminoethylether)-N, N, N ', N'-tetra-eddikesyre syre), måles.

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Bioteknik Organiske bioelektronik stramme vejkryds paracellulære transport EGTA barriere væv toksikologi biosensorer organisk elektrokemisk transistor
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