分子构象和群集的空间分离

Engineering

Your institution must subscribe to JoVE's Engineering section to access this content.

Fill out the form below to receive a free trial or learn more about access:

 

Cite this Article

Copy Citation | Download Citations | Reprints and Permissions

Horke, D., Trippel, S., Chang, Y. P., Stern, S., Mullins, T., Kierspel, T., Küpper, J. Spatial Separation of Molecular Conformers and Clusters. J. Vis. Exp. (83), e51137, doi:10.3791/51137 (2014).

Please note that all translations are automatically generated.

Click here for the english version. For other languages click here.

Abstract

Materials

Name Company Catalog Number Comments
Vacuum system various, e.g. Pfeiffer Vacuum, Varian, Edwards, Leybold
Dye laser system various, e.g. Coherent, Spectra Physics, Syrah, LIOP-TEC, Radiant Dyes…
Pulsed valve Even-Lavie
High voltage power supply eg. FUG HCP 14-20000
Deflector Custom made
Time-of-flight spectrometer Jordan TOF C-677
TOF power supply Jordan TOF D-603
Focusing lens Thorlabs LA4745
Translation stage e.g. Vision Lasertechnik 8MT167-25
Digitizer e.g. Agilent Acquiris DC440
Digital delay generator Stanford Systems SRS DG645
Molecular beam skimmer Beam Dynamics Inc. http://www.beamdynamicsinc.com/

DOWNLOAD MATERIALS LIST

References

  1. Rizzo, T. R., Park, Y. D., Peteanu, L., Levy, D. H. Electronic spectrum of the amino acid tryptophan cooled in a supersonic molecular beam. J. Chem. Phys. 83, 4819-4820 (1985).
  2. Itatani, J., et al. Tomographic imaging of molecular orbitals. Nature. 432, 867-871 (2004).
  3. Kumarappan, V., et al. Multiphoton electron angular distributions from laser-aligned CS2 molecules. Phys. Rev. Lett. 100, (9), 093006-0910 (2008).
  4. Bisgaard, C. Z., et al. Time-resolved molecular frame dynamics of fixed-in-space CS2 molecules. Science. 323, (5920), 1464-1468 (2009).
  5. Holmegaard, L., et al. Photoelectron angular distributions from strong-field ionization of oriented molecules. Nat. Phys. 6, 428-4210 (2010).
  6. Ihee, H., et al. Direct imaging of transient molecular structures with ultrafast diffraction. Science. 291, (5503), 458-462 (2001).
  7. Chergui, M., Zewail, A. H. Electron and x-ray methods of ultrafast structural dynamics: Advances and applications. Chem. Phys. Chem. 10, (1), 28-43 (2009).
  8. Siwick, B. J., Dwyer, J. R., Jordan, R. E., Miller, R. J. D. An atomic-level view of melting using femtosecond electron diffraction. Science. 302, (5649), 1382-1385 (2003).
  9. Sciaini, G., Miller, R. J. D. Femtosecond electron diffraction: heralding the era of atomically resolved dynamics. Rep. Prog. Phys. 74, (9), 096101-0910 (2011).
  10. Hedberg, K., et al. Bond lengths in free molecules of buckminsterfullerene, C60, from gas-phase electron diffraction. Science. 254, (5030), 410-412 (1991).
  11. Filsinger, F., Meijer, G., Stapelfeldt, H., Chapman, H., Küpper, J. S. tate- and conformerselected beams of aligned and oriented molecules for ultrafast diffraction studies. Phys. Chem. Chem. Phys. 13, (6), 2076-2087 (2011).
  12. Seibert, M. M., et al. Single mimivirus particles intercepted and imaged with an x-ray laser. Nature. 470, (7332), (2011).
  13. Chapman, H. N., et al. Femtosecond x-ray protein nanocrystallography. Nature. 470, (7332), (2011).
  14. von Helden, G., Wyttenbach, T., Bowers, M. T. Conformation of macromolecules in the gasphase – use of matrix-assisted laser-desorption methods in ion chromatography. Science. 267, 1483-1485 (1995).
  15. Jarrold, M. Helices and sheets in vacuo. Phys. Chem. Chem. Phys. 9, 1659-1671 (2007).
  16. Filsinger, F., et al. Pure samples of individual conformers: the separation of stereo-isomers of complex molecules using electric fields. Angew. Chem. Int. Ed. 48, (2009).
  17. Filsinger, F., et al. Quantum-state selection, alignment, and orientation of large molecules using static electric and laser fields. J. Chem. Phys. 131, 10-1063 (2009).
  18. Kallmann, H., Reiche, F. Über den Durchgang bewegter Moleküle durch inhomogene Kraftfelder. Z. Phys. 6, 352-375 (1921).
  19. Wrede, E. Über die Ablenkung von Molekularstrahlen elektrischer Dipolmoleküle im inhomogenen elektrischen Feld. Z. Phys. 44, (4-5), 4-5 (1927).
  20. Gerlach, W., Der Stern, O. experimentelle Nachweis der Richtungsquantelung im Magnetfeld. Z. Phys. 9, 349-352 (1922).
  21. Trippel, S., Chang, Y. -P., Stern, S., Mullins, T., Holmegaard, L., Küpper, J. Spatial separation of state- and size-selected neutral clusters. Phys. Rev. A. 86, 10-1103 (2012).
  22. Filsinger, F., Erlekam, U., von Helden, G., Küpper, J., Meijer, G. Selector for structural isomers of neutral molecules. Phys. Rev. Lett. 100, 10-1103 (2008).
  23. Filsinger, F., Putzke, S., Haak, H., Meijer, G., Küpper, J. Tuning the resolution of the m=_- selector. Phys. Rev. A. 82, 052513-0510 (2010).
  24. Putzke, S., Filsinger, F., Haak, H., Küpper, J., Meijer, G. Rotational-state-specific guiding of large molecules. Phys. Chem. Chem. Phys. 13, (2011).
  25. Nielsen, J. H., et al. Stark-selected beam of ground-state OCS molecules characterized by revivals of impulsive alignment. Phys. Chem. Chem. Phys. 13, 18971-18975 (2011).
  26. Stapelfeldt, H., Seideman, T. Colloquium: Aligning molecules with strong laser pulses. Rev. Mod. Phys. 75, (2), 543-557 (2003).
  27. Holmegaard, L., et al. Laser-induced alignment and orientation of quantum-state-selected large molecules. Phys. Rev. Lett. 102, 10-1103 (2009).
  28. Ghafur, O., Rouzee, A., Gijsbertsen, A., Siu, W. K., Stolte, S., Vrakking, M. J. J. Impulsive orientation and alignment of quantum-state-selected NO molecules. Nat. Phys. 5, 289-293 (2009).
  29. Hillenkamp, M., Keinan, S., Even, U. Condensation limited cooling in supersonic expansions. J. Chem. Phys. 118, (19), 8699-8705 (2003).
  30. Ramsey, N. F. Molecular Beams. The International Series of Monographs on Physics. Oxford University Press. London, GB. (1956).
  31. Nielsen, J. H., Stapelfeldt, H., Küpper, J., Friedrich, B., Omiste, J. J., González-Férez, R. Making the best of mixed-field orientation of polar molecules: A recipe for achieving adiabatic dynamics in an electrostatic field combined with laser pulses. Phys. Rev. Lett. 108, (19), 10-1103 (2012).
  32. Fujimaki, E., Fujii, A., Ebata, T., Mikami, N. Autoionization-detected infrared spectroscopy of intramolecular hydrogen bonds in aromatic cations. I. principle and application to fluorophenol and methoxyphenol. J. Chem. Phys. 110, 4238-4247 (1999).
  33. Kang, C., Korter, T. M., Pratt, D. W. Experimental measurement of the induced dipole moment of an isolated molecule in its ground and electronically excited states: Indole and indole–H2O. J. Chem. Phys. 122, (17), 174301-17 (2005).
  34. Korter, T. M., Pratt, D. W., Küpper, J. Indole-H2O in the gas phase. structures, barriers to internal motion, and S1 S0 transition moment orientation. solvent reorganization in the electronically excited state. J. Phys. Chem. A. 102, (37), 7211-7216 (1998).
  35. Küpper, J., Pratt, D. W., Meerts, L., Brand, C., Tatchen, J., Schmitt, M. Vibronic coupling in indole: II. experimental investigation of the 1La–1Lb interaction using rotationally resolved electronic spectroscopy. Phys. Chem. Chem. Phys. 12, 4980-4988 (2010).
  36. Suenram, R. D., Lovas, F. J. Millimeter wave spectrum of glycine - a new conformer. J. Am. Chem. Soc. 102, 7180-7184 (1980).
  37. Nir, E., Kleinermanns, K., de Vries, M. S. Pairing of isolated nucleic-acid bases in the absence of the DNA backbone. Nature. 408, 949-951 (2000).
  38. Bethlem, H. L., van Roij, A. J. A., Jongma, R. T., Meijer, G. Alternate gradient focusing and deceleration of a molecular beam. Phys. Rev. Lett. 88, (13), 10-1103 (2002).
  39. Wohlfart, K., Grätz, F., Filsinger, F., Haak, H., Meijer, G., Küpper, J. Alternating-gradient focusing and deceleration of large molecules. Phys. Rev. A. 77, 10-1103 (2008).
  40. Putzke, S., Filsinger, F., Küpper, J., Meijer, G. Alternating-gradient focusing of the benzonitrile-argon van der waals complex. J. Chem. Phys. 137, (10), 10-1063 (2012).
  41. Knight, W. D., Clemenger, K., de Heer, W. A., Saunders, W. A. Polarizability of alkali clusters. Phys. Rev. B. 31, (4), 2539-2540 (1985).
  42. Tarnovsky, V., Bunimovicz, M., Vuškovic, L., Stumpf, B., Bederson, B. Measurements of the DC electric-dipole polarizabilities of the alkali dimer molecules, homonuclear and heteronuclear. J. Chem. Phys. 98, (5), 3894-3904 (1993).
  43. Schäfer, R., Schlecht, S., Woenckhaus, J., Becker, J. Polarizabilities of Isolated Semiconductor Clusters. Phys. Rev. Lett. 76, (3), 471-474 (1996).
  44. Antoine, R., et al. Electric dipole moments and conformations of isolated peptides. Eur. Phys. J. D. 20, 583-587 (2002).
  45. Cosby, P. C., Smith, G. P., Moseley, J. T. Photodissociation and photodetachment of molecular negative ions. IV. Hydrates of O. J. Chem. Phys. 69, 2779-2781 (1978).
  46. Hunton, D. E., Hofmann, M., Lindeman, T. G., Albertoni, C. R., Castleman Jr,, W, A. Photodissociation spectroscopy and dynamics of negative ion clusters. II. CO. (H2O)1;2;3. J. Chem. Phys. 82, 2884-2895 (1985).
  47. Castleman, A. W., Bowen J, K. H., J, Clusters: Structure, energetics, and dynamics of intermediate states of matter. J. Phys. Chem. 100, 12911-12944 (1996).
  48. Verlet, J. R. R. Femtosecond spectroscopy of cluster anions: insights into condensed-phase phenomena from the gas-phase. Chem. Soc. Rev. 37, 505-517 (2008).
  49. Nevo, I., et al. Laser-induced 3D alignment and orientation of quantum state-selected molecules. Phys. Chem. Chem. Phys. 11, 9912-9918 (2009).
  50. Reckenthaeler, P., Centurion, M., Fuss, W., Trushin, S. A., Krausz, F., Fill, E. E. Time-resolved electron diffraction from selectively aligned molecules. Phys. Rev. Lett. 102, (21), 213001-2110 (2009).

Comments

1 Comment

  1. fantastic!

    Reply
    Posted by: Xudong W.
    February 22, 2014 - 3:54 AM

Post a Question / Comment / Request

You must be signed in to post a comment. Please or create an account.

Usage Statistics