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Journal / Medicine / Inledande av metastaserande Bröstkarcinom genom…
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Inledande av metastaserande Bröstkarcinom genom Inriktning av Ductal epitel med adenovirus-Cre
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Inledande av metastaserande Bröstkarcinom genom Inriktning av Ductal epitel med adenovirus-Cre: A Novel transgen musmodell av bröstcancer

Article DOI: 10.3791/51171-v • 07:14 min • March 26th, 2014
March 26th, 2014 •
*1, *1, 1, 1, 1, 1, 1, 2, 3, 4,5,6, 1
1Tumor Microenvironment and Metastasis Program, Wistar Institute, 2Department of Pathology and Lab Medicine, Perelman School of Medicine, University of Pennsylvania, 3Department of Microbiology and Immunology and Department of Genetics, Geisel School of Medicine at Dartmouth, 4Division of Endocrine and Oncologic Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, 5Rena Rowan Breast Center, Abramson Cancer Center, University of Pennsylvania, 6Center for Advanced Medicine, University of Pennsylvania
* These authors contributed equally

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Aktivering av latenta mutationer med adenovirus-Cre i bröst duktal systemet resulterar i en kliniskt relevant metastaserande bröstcancer. Införande av en YFP promotor möjliggör spårning av distala metastaserande tumörceller. Denna modell är användbar för att studera latent metastaser, antitumörimmunitet, och för att utforma nya immunterapier för behandling av bröstcancer.

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Medicine Transgena möss bröstcancer metastasis intraductal injektion latenta mutationer adenovirus-Cre
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