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In Vivo Optical Imaging af hjernetumorer og Gigt Brug Fluorescent SAPC-DOPS Nanovesicles

Article DOI: 10.3791/51187-v • 09:04 min • May 2nd, 2014
May 2nd, 2014 •
1,2, 3, 1, 5,6, 5,6, 4, 4, 3, 1,2
1Division of Hematology-Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, 2Division of Human Genetics, University of Cincinnati College of Medicine, 3Department of Radiology, University of Cincinnati College of Medicine, 4Division of Rheumatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 5Solid Tumor Biology Program, James Comprehensive Cancer Center, The Ohio State University Medical Center, 6Department of Neurological Surgery, James Comprehensive Cancer Center, The Ohio State University Medical Center

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Vi beskriver en multi-vinkel roterende optisk imaging (Maroi) system for in vivo kvantificering af en fluorescerende markør leveret af saposin K (SAPC)-dioleoylphosphatidylserin (DOPS) nanovesicles. Anvender musemodeller af kræft og gigt, vi vise, hvordan Maroi signal kurve analyse kan anvendes til en præcis kortlægning og biologisk karakterisering af sygdomsprocesser.

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Medicine saposin K (SAPC) dioleoylphosphatidylserin (DOPS) Brain tumor gigt fluorophor fluorescens optisk billeddannelse Multi-vinkel roterende optisk imaging (Maroi)
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